Fig. 1 · Structure
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Ecopipam
D1/D5 Antagonist
Ecopipam is a potent and selective antagonist of the dopamine D1 and D5 receptors, displaying inhibition constants (Kis) of 1.2 nM and 2.0 nM, respectively. It exhibits over 40-fold selectivity against D2, D4, 5-HT, and α2a receptors, with Kis of 0.98 μM, 5.52 μM, 0.08 μM, and 0.73 μM, respectively. Ecopipam is primarily utilized in research related to schizophrenia and obesity, offering insights into the modulation of dopaminergic signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 112108-01-7 |
| Applications | D1/D5 Antagonist |
| Formula | C19H20ClNO |
| Molecular Weight | 313.82 |
| Synonyms | SCH 39166 |
| SMILES | OC1=C(Cl)C=C2C([C@]3([H])[C@@](CCC4=C3C=CC=C4)([H])N(C)CC2)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.