Fig. 1 · Structure
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Emestrin
Antimicrobial Agent
Emestrin is a mycotoxin derived from E. striata, functioning primarily as an antimicrobial agent. It demonstrates significant activity against various fungi, including C. albicans and C. neoformans, as well as multiple bacteria, such as E. coli and MRSA, with IC50 values ranging from 0.6 to 4.55 μg/mL. Additionally, Emestrin acts as a CCR2 antagonist with an IC50 of 5.4 μM in isolated human monocytes and has been shown to induce apoptosis in HL-60 cells at a concentration of 0.1 μg/mL. In vivo studies indicate that Emestrin can induce tissue necrosis in heart, thymus, and liver at doses between 18 to 30 mg/kg in mice.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 97816-62-1 |
| Applications | Antimicrobial Agent |
| Formula | C27H22N2O10S2 |
| Molecular Weight | 598.60 |
| SMILES | COC(C(OC1=C(O)C=CC2=C1)=C3)=CC=C3C(O[C@H]4C=COC=C([C@]54[H])[C@@H](O)[C@@](N5C([C@]6([C@H]2O)N7C)=O)(SS6)C7=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.