Biological Activity
EN6 is a novel covalent autophagy activator, targeting cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase, which activates mTORC1 via the Rag guanosine triphosphatases.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 27.15 mL | 135.74 mL | 271.49 mL |
0.5 mM | 5.43 mL | 27.15 mL | 54.3 mL |
1 mM | 2.71 mL | 13.57 mL | 27.15 mL |
5 mM | 0.54 mL | 2.71 mL | 5.43 mL |
*The above data is based on the productmolecular weight 368.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A18524 |
---|---|
Actions | Activator |
M. Wt | 368.34 |
Formula | C19H14F2N4O2 |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1808714-73-9 |
Synonyms | EN6; EN-6; EN 6 |
SMILES | O=C(C1=CN(C2=CC=CC=C2F)N=C1)NC3=CC=C(F)C(NC(C=C)=O)=C3 |
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