Fig. 1 · Structure
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Epetraborole (R-mandelate)
LeuRS Inhibitor
Epetraborole (R-mandelate) is a potent inhibitor of leucyl-tRNA synthetase (LeuRS) with an IC50 value of 0.31 μM, effectively blocking protein synthesis. This compound is valuable for research involving multidrug-resistant gram-negative bacterial infections, contributing to the development of alternative therapeutic strategies. Its mechanism of action makes it a critical tool for investigating resistance mechanisms and improving antibiotic efficacy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1234563-15-5 |
| Applications | LeuRS Inhibitor |
| Formula | C19H24BNO7 |
| Molecular Weight | 389.21 |
| Synonyms | GSK-2251052 (R-mandelate); AN 3365 (R-mandelate) |
| SMILES | OC([C@@H](C1=CC=CC=C1)O)=O.OCCCOC2=C3C([C@H](OB3O)CN)=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.