Sirtuins | Adooq Bioscience

Cat. No.: A56960

CAS No.: 2070015-26-6

Sirtuin modulator 1

Sirtuin Modulator 1 is a selective modulator of SIRT1, a member of the sirtuin family of NAD+-dependent deacetylases. With an effective concentration of less than 1 μM, it demonstrates significant biological activity in the regulation of cellular aging and metabolism. This reagent holds potential for research applications in studying age-related diseases, metabolic disorders, and the mechanisms of epigenetic regulation mediated by sirtuins.

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5 mg

$25.00

10 mg

$40.00

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Cat. No.: A56971

CAS No.: 476633-98-4

Sirtuin modulator 6

Sirtuin modulator 6 is a selective modulator of sirtuin proteins, known for its role in enhancing cellular longevity. This compound exhibits potential therapeutic effects in the context of metabolic disorders such as diabetes and obesity, as well as neurodegenerative and cardiovascular diseases. Its mechanism of action supports research into the modulation of sirtuin pathways, providing insights into various age-related health conditions.

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1 mg

$45.00

5 mg

$115.00

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Cat. No.: A56990

CAS No.: 163136-19-4

Cannabisin F

Cannabisin F is a modulator of SIRT1, derived from hempseed lignanamide. It exhibits significant anti-inflammatory and antioxidant properties, making it a valuable candidate for research focused on neurodegenerative diseases. Cannabisin F may influence critical pathways involving SIRT1, NF-κB, and Nrf2, contributing to its potential therapeutic applications.

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Cat. No.: A56992

CAS No.: 708995-11-3

Sirtuin modulator 3

Sirtuin modulator 3 is a N-phenyl benzamide derivative that functions as a sirtuin modulator. This compound has been shown to influence sirtuin activity, which is implicated in various biological processes, including aging and cellular regulation. Its biological activity makes it a valuable tool for research in the fields of metabolism, epigenetics, and age-related diseases.

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5 mg

$40.00

10 mg

$65.00

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Cat. No.: A57017

CAS No.: 863589-21-3

SIRT1-IN-5

SIRT1-IN-5 is a selective modulator of the NAD-dependent protein deacetylase SIRT1. It demonstrates significant activity in regulating deacetylation processes, contributing to cellular metabolism and stress response. This compound can be utilized in research focused on aging, metabolic diseases, and neurodegenerative disorders, making it a valuable tool for exploring the therapeutic potential of SIRT1 modulation.

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1 mg

$155.00

5 mg

$395.00

All 6 sizes

Cat. No.: A57025

CAS No.: 2303528-97-2

IMU-856

IMU-856 is a small molecule modulator of SIRT6, exhibiting oral bioavailability and systemic action. It selectively inhibits the deacetylase activity of SIRT6 while simultaneously increasing its protein levels. This compound has demonstrated the ability to restore intestinal barrier function, making it a valuable tool for research on celiac disease and related gastrointestinal disorders.

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Cat. No.: A57028

CAS No.: 2309398-79-4

FLS-359

FLS-359 is an orally active allosteric modulator of sirtuin 2, demonstrating an IC50 of 3 μM. This compound exhibits significant antiviral activity, effectively inhibiting both RNA and DNA viral replication. FLS-359 is valuable for research applications focused on viral pathogenesis and therapeutic strategies targeting sirtuin signaling pathways.

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5 mg

$230.00

10 mg

$375.00

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Cat. No.: A57030

CAS No.: 667910-69-2

Sirtuin modulator 2

Sirtuin Modulator 2 (Compound 132) is a selective modulator of sirtuin enzymes, exhibiting an effective dose (ED50) of 50 μM or lower. This compound plays a critical role in the regulation of cellular processes such as aging, metabolism, and stress response. Its ability to influence sirtuin activity makes it valuable for research in fields like cancer biology, neurodegenerative diseases, and metabolic disorders.

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5 mg

$35.00

10 mg

$55.00

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Cat. No.: A57034

CAS No.: 339156-78-4

SIRT6 modulator-1

SIRT6 modulator-1 is a selective modulator of SIRT6, a key enzyme involved in regulating metabolic processes and DNA repair. This compound influences SIRT6 activity, enhancing its role in chromatin dynamics and cellular stress responses. SIRT6 modulator-1 has potential applications in research focused on aging, metabolic disorders, and cancer by elucidating the pathways regulated by SIRT6.

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Cat. No.: A72504

CAS No.: 652968-37-1

MitoPBN

MitoPBN is an AMPK/SIRT3/PGC-1α modulator that enhances mitochondrial function by acting as a reactive oxygen species scavenger. This compound promotes mitochondrial biogenesis through increased AMPK phosphorylation, restoration of SIRT3 expression, and upregulation of PGC-1α. MitoPBN is effective in regulating glucose metabolism, as it decreases blood glucose levels by inhibiting hepatic gluconeogenesis and enhancing glucose uptake, while also improving ATP production and maintaining mitochondrial membrane potential. Additionally, it can reduce apoptosis and enhance sperm motility and membrane integrity, making it a valuable reagent for research related to diabetes and metabolic disorders.

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Cat. No.: A76754

CAS No.: 863589-28-0

Sirtuin modulator 9

Sirtuin Modulator 9 is a sirtuin-modulating compound that enhances cellular lifespan and promotes mitochondrial activity. This compound has potential applications in research related to aging, inflammation, and cancer. Investigators may utilize Sirtuin Modulator 9 to explore its therapeutic effects in age-related disorders and diseases associated with compromised mitochondrial function.

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