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Human Antigen R (HuR)

HuR inhibitors target an RNA-binding protein that stabilizes many short-lived messenger RNAs. Human antigen R (HuR) was cloned in 1996 as a ubiquitously expressed member of the embryonic lethal abnormal vision (ELAV)-like protein family. HuR binds adenylate-uridylate-rich elements (AREs) in the 3' untranslated regions of messenger RNAs (mRNAs) for cytokines, growth factors and cell-cycle regulators. A 1998 study showed that HuR shuttles between nucleus and cytoplasm and that its overexpression stabilizes ARE-containing mRNAs. CMLD-2 and KH-3 disrupt HuR binding to ARE-containing RNA, while SRI-42127 blocks its movement to the cytoplasm. MG-HuR2 and HuR degrader 2 are listed as molecular glue compounds directed at HuR.

2 Items

  • HuR degrader 2
    Cat. No.
    A57787
    CAS No.
    3040301-46-7

    HuR degrader 2

    HuR degrader 2 is a molecular glue that specifically targets the RNA-binding protein Hu antigen R (HuR), leading to a significant degradation of approximately 30% of HuR at a concentration of 0.1 μM. This compound effectively inhibits the proliferation of the Colo-205 cancer cell line, demonstrating an IC50 of ≤200 nM. Additionally, HuR degrader 2 shows a high affinity for cereblon, with an HTRF ratio of less than 0.02, making it a valuable tool for studying HuR's role in cancer biology.

    In stock View Details
    5 mg
    $280.00
    10 mg
    $460.00
    All 4 sizes
  • MG-HuR2
    Cat. No.
    A57788
    CAS No.
    3098773-64-6

    MG-HuR2

    MG-HuR2 is a molecular glue degrader that specifically targets the oncogenic RNA-binding protein HuR, exhibiting an IC50 of 0.5 μM. This compound is particularly relevant for research involving HuR-overexpressing malignancies, such as breast cancer, providing a valuable tool for investigating therapeutic strategies aimed at modulating HuR activity in cancerous tissues.

    In stock View Details
    5 mg
    $65.00
    10 mg
    $105.00
    All 6 sizes

2 Items

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