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Protein Arginine Deiminase (PAD)

Protein arginine deiminase (PAD) inhibitors block enzymes that convert peptidyl arginine into citrulline. The reaction, called citrullination or deimination, removes a positive charge and changes protein folding and interactions. Humans have five calcium-dependent isozymes, PAD1 to PAD4 and PAD6. PAD4 enters the nucleus and citrullinates histones, a modification shown in 2004 to counteract arginine methylation. Histone hypercitrullination by PAD4 also drives chromatin decondensation during neutrophil extracellular trap (NET) formation. Cl-amidine and BB-Cl-Amidine are irreversible inhibitors that act on several PAD isozymes. GSK484 hydrochloride and GSK199 are reversible PAD4-selective compounds, and GSK484 disrupted NET formation in mouse and human neutrophils in 2015.

Cat. No.

A46273

CAS No.

301338-95-4

DFPM

DFPM is a plant resistance protein activator that modulates signaling pathways in roots, resulting in root growth arrest. This compound has been shown to decrease root cell viability in the Col-0 accession. Notably, DFPM exhibits light sensitivity in aqueous solutions and becomes bioactive through light and oxygen-dependent modifications, making it a valuable tool for studying plant defense mechanisms and root development processes.

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1 mg

$75.00

5 mg

$515.00

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Protein Arginine Deiminase (PAD)

DFPM