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HDAC

Histone deacetylase (HDAC) inhibitors block enzymes that remove acetyl groups from histones and other proteins. Deacetylation compacts chromatin and generally represses transcription, so HDAC inhibitors are widely used to study gene regulation. Trichostatin A was characterized in 1990 as a specific inhibitor of mammalian histone deacetylase. The first mammalian HDAC was cloned in 1996 and found to be related to the yeast transcriptional regulator Rpd3p. Isoform-selective tools include entinostat for HDAC1 and HDAC3, and Tubastatin A HCl for HDAC6, a microtubule-associated deacetylase. Broad-spectrum hydroxamates such as vorinostat and panobinostat, together with the cyclic depsipeptide romidepsin, complete the range.

4 Items

  • VUBI1 analogue-1
    Cat. No.
    A24799
    CAS No.
    2245237-61-8

    VUBI1 analogue-1

    VUBI1 analogue-1 is an analogue of VUBI1, functioning as a selective activator of the SOS1 pathway with a Kd of 44 nM. This compound is valuable for studying SOS1 activation mechanisms and provides a basis for the synthesis of (4S)-PROTAC SOS1 degrader-1. Its applications include investigations into targeted degradation and modulation of cellular pathways involving SOS1, offering insights into cellular signaling and potential therapeutic strategies.

    In stock View Details
    5 mg
    $140.00
    10 mg
    $250.00
    All 5 sizes
  • G194-0712
    Cat. No.
    A26411
    CAS No.
    1029737-28-7

    G194-0712

    G194-0712 is a selective activator of histone deacetylase 5 (HDAC5), exhibiting an EC50 of 7.96 μM and a Kd of 2.53 μM. This compound promotes ACTN4-K417 deacetylation and enhances nuclear import while upregulating CSTA expression. G194-0712 has demonstrated efficacy in accelerating wound closure in chronic wound models, particularly in reducing wound area and epithelial gaps. Its applications extend to the study of chronic skin wounds, including diabetic, ischemic, and radiation injury-related wounds.

    In stock View Details
    5 mg
    $220.00
    10 mg
    $360.00
    All 4 sizes
  • Curcuphenol
    Cat. No.
    A26431
    CAS No.
    69301-27-5

    Curcuphenol

    Curcuphenol is a histone deacetylase (HDAC) activator known for its ability to reverse immune escape mechanisms in tumor cells. By restoring the expression of antigen presentation machinery, Curcuphenol enhances immune recognition of metastatic tumors. Its synthetic analogs also exhibit similar HDAC-enhancing activity, making them valuable tools for research focused on tumor immunology and potential therapeutic strategies in cancer.

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    Out of stock

    All 3 sizes
  • HDAC1 activator-1
    Cat. No.
    A26494
    CAS No.
    300399-36-4

    HDAC1 activator-1

    HDAC1 activator-1 is a selective activator of histone deacetylase 1 (HDAC1), demonstrating oral bioavailability and minimal cross-reactivity with other HDAC family members. This compound exhibits neuroprotective properties, enhancing cognitive and motor functions by mitigating neuronal loss and gliosis. HDAC1 activator-1 effectively activates HDAC1 in SH-SY5Y neuroblastoma cells, influencing cell cycle regulation and DNA damage responses. It is applicable in research investigating TDP-43 proteinopathy-related neurodegenerative disorders, including Amyotrophic Lateral Sclerosis (ALS) and cerebral ischemia-associated neurological injuries.

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    Out of stock

    All 3 sizes

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