BODIPY Dyes

Cat. No.

A24506

CAS No.

730931-46-1

ER-Tracker Green

ER-Tracker dye is a BODIPY-based fluorescent probe conjugated with Glibenclamide, exhibiting high selectivity for the endoplasmic reticulum (ER). It is cell-permeable, non-toxic at low concentrations, and retains partial fluorescence after formaldehyde fixation. As an environment-sensitive dye, R-Tracker offers a long fluorescence lifetime and a high extinction coefficient. Glibenclamide, an ATP-sensitive K⁺ channel (Kir6.x, KATP) and CFTR Cl⁻ channel blocker, mediates ER targeting. R-Tracker is not suitable for post-fixation staining.

Cat. No.

A24518

CAS No.

878557-19-8

BODIPY-Cholesterol

BODIPY-cholesterol is a lipophilic, cell-permeable fluorescent analog of cholesterol, labeled with a BODIPY fluorophore (Ex/Em: 505/515 nm). It is commonly used to monitor sterol uptake, distribution, and inter-organelle trafficking in live cells.

Cat. No.

A24539

CAS No.

217075-36-0

BODIPY 581/591 C11

BODIPY 581/591 C11 is a boron-dipyrromethene (BODIPY) derivative with excellent photostability and minimal fluorescence artifacts. It is widely used to study lipid peroxidation and antioxidant activity in living cells, and to detect ferroptosis through its reaction with hydroxyl radicals. The dye exhibits a fluorescence shift upon oxidation: the reduced form emits at 591 nm (Ex: 581 nm), while the oxidized form emits at 510 nm (Ex: 500 nm).

Cat. No.

A24586

CAS No.

158757-84-7

BODIPY 558/568 C12

BODIPY 558/568 C12 is a fluorescent lipid probe based on the BODIPY (boron-dipyrromethene) dye structure. BODIPY dyes are small-molecule fluorophores characterized by strong ultraviolet-visible absorption, sharp fluorescence emission peaks, high quantum yields, and remarkable photostability. They are largely insensitive to environmental polarity and pH, maintaining consistent fluorescence under various physiological conditions. BODIPY 558/568 C12, due to its lipophilic alkyl chain, readily permeates cell membranes and specifically localizes to neutral lipid compartments, enabling selective staining of lipid droplets in both live and fixed cells. It serves as a reliable fluorescent marker for studying lipid metabolism, lipid droplet dynamics, and cellular lipid distribution. The dye exhibits maximum excitation and emission wavelengths at 558 nm and 568 nm, respectively.

Cat. No.

A24601

CAS No.

216434-81-0

BODIPY 493/503 methyl bromide

BODIPY493/503 methyl bromide is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells. Maximum excitation/emission wavelength: 493/503 nm.

Cat. No.

A24603

CAS No.

121207-31-6

BODIPY 493/503 (Pyrromethene 546)

Synonyms: Pyrromethene 546

BODIPY 493/503 is a member of the BODIPY (boron-dipyrromethene) family of small-molecule fluorescent dyes, characterized by strong absorption in the ultraviolet-visible range, narrow and well-defined emission spectra, and high fluorescence quantum yields. These dyes exhibit minimal sensitivity to environmental polarity and pH, maintaining stable photophysical properties under a wide range of physiological conditions. Due to the structural versatility of the BODIPY core, numerous derivatives with tailored properties can be generated. BODIPY-based lipid droplet probes readily permeate cellular membranes and selectively localize to neutral lipid compartments, enabling specific staining of intracellular lipid droplets. This makes them suitable for both live-cell imaging and fixed-cell applications. Maximum excitation/emission wavelengths: 493/503 nm.

Cat. No.

A24759

CAS No.

165599-63-3

BODIPY-FL

Synonyms: BDP FL acid

BODIPY-FL is a green fluorescent dye primarily utilized for labeling biological probes and primers. It exhibits unique fluorescence quenching capabilities upon interaction with specific guanine positioning, making it effective for quantifying particular DNA or RNA molecules. With a maximum absorption wavelength of 505 nm and an emission wavelength of 513 nm, BODIPY-FL is a valuable tool in nucleic acid detection and analysis applications.

Cat. No.

A24897

CAS No.

21658-70-8

BODIPY 505/515

BODIPY 505/515 is a lipophilic fluorescent dye with a strong ultraviolet absorption capacity and sharp fluorescence peak, offering a high quantum yield. This compound exhibits stability across various physiological conditions and is relatively insensitive to environmental polarity and pH. BODIPY 505/515 effectively penetrates cell membranes, allowing specific labeling of neutral lipids within lipid droplets in both live and fixed cells. It is ideal for applications in cellular imaging, studying lipid metabolism, and analyzing cellular lipid storage. Maximum excitation and emission wavelengths are 505 nm and 515 nm, respectively.

Cat. No.

A24901

CAS No.

1392820-50-6

MitoPerOx

MitoPerOx is a fluorescent probe designed to detect lipid peroxidation specifically in mitochondria, utilizing BODIPY581/591 fluorophores. With its triphenylphosphine cation (TPP+), MitoPerOx selectively accumulates in mitochondria based on membrane potential, allowing for sensitive measurement of lipid peroxides within the inner mitochondrial membrane. The probe exhibits a ratiometric emission shift from 590 nm to 520 nm upon oxidation, facilitating accurate detection at an excitation wavelength of 488 nm. MitoPerOx is valuable for investigating oxidative stress-associated diseases, including aging, neurodegenerative disorders, and mitochondrial dysfunction.

Cat. No.

A24911

CAS No.

133867-53-5

BODIPY FL C5-Ceramide

BODIPY FL C5-Ceramide is a Golgi-specific fluorescent dye that targets the Golgi apparatus for precise cellular visualization. This BODIPY-labeled ceramide derivative is synthesized in the endoplasmic reticulum and is effectively transported to the Golgi through ceramide transport proteins or vesicular mechanisms. With an excitation/emission wavelength of 505 nm/512 nm, it is suited for applications in cell biology and imaging studies, allowing researchers to observe and analyze cellular structures with enhanced clarity.

Cat. No.

A24914

CAS No.

1029138-21-3

BODIPY-C12

BODIPY-C12 is a boron-dipyrromethene derivative functioning as a fluorescent probe with an excitation wavelength of 490 nm. Its hydrophobic structure allows it to be highly sensitive to its surrounding environment, making it suitable for quantifying viscosity, critical micelle concentration, and critical micelle temperature. This compound serves as a valuable tool for researchers in assessing lipid environment dynamics and micelle formation in various biological studies.

Cat. No.

A24921

CAS No.

144672-74-2

BODIPY 500/510 C1, C12

BODIPY 500/510 C1, C12 is a fluorescent dye characterized by strong ultraviolet absorption and high quantum yield. It features a sharp fluorescence peak and remains stable across various physiological conditions, demonstrating minimal sensitivity to polarity and pH variations. This dye effectively penetrates cell membranes, allowing for the specific localization of neutral lipids within lipid droplets in both live and fixed cells. It is widely utilized for cellular imaging and lipid droplet labeling applications. Maximum excitation and emission wavelengths are 500 nm and 510 nm, respectively. Protect from light and store at -20°C.

Cat. No.

A24952

CAS No.

217075-07-5

BODIPY FL-DHPE

BODIPY FL-DHPE is a green-fluorescent phospholipid probe targeting lipid bilayers. It labels 1,2-dihexadecanoyl-sn-glycero-phosphoethanolamine (DHPE), facilitating the study of membrane dynamics through membrane fusion processes. This reagent is ideal for investigating membrane structure and function in various cellular contexts, as well as analyzing lipid interactions in live cell imaging applications. The excitation and emission wavelengths are λex=505 nm and λem=511 nm, respectively.

Cat. No.

A25032

CAS No.

886212-87-9

10-(4-(Bis(2-acetoxyethyl)amino)phenyl)-BODIPY 505/515

10-(4-(Bis(2-acetoxyethyl)amino)phenyl)-BODIPY 505/515 is a highly sensitive fluorescent dye specifically designed for the detection of Cu2+ ions. This compound exhibits enhanced fluorescence properties upon binding to copper ions, making it a valuable tool for studying metal ion distribution and dynamics in biological systems. Its application extends to fluorescence imaging and sensing in various research contexts, including environmental monitoring and biological assays.

Cat. No.

A26889

CAS No.

3030055-40-1

CAR-2

CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis through its action on the endoplasmic reticulum and lipid droplets. This compound demonstrates significant phototoxicity in breast cancer cells, with an IC50 ranging from 0.01 to 0.02 μM. Additionally, CAR-2 shows promising antitumor efficacy in 4T1 xenograft mouse models, making it a valuable tool for photodynamic therapy research.

Cat. No.

A39028

CAS No.

1083009-44-2

BDPI

BDPI is a BODIPY derivative that functions as a cell imaging agent through its high O2 quantum yield and phototoxic properties. This compound demonstrates significant antitumor activity by inhibiting HeLa cell proliferation with an IC50 of 0.6 µg/mL. BDPI nanoparticles are effectively internalized by HeLa cells, producing fluorescence signals that facilitate cellular imaging. Additionally, BDPI has shown antitumor efficacy in in vivo mouse models, supporting its potential applications in cancer research.

Cat. No.

A43750

CAS No.

250734-47-5

8-(4-Iodophenyl)-1,3,5,7-tetramethyl BODIPY

8-(4-Iodophenyl)-1,3,5,7-tetramethyl BODIPY is a BODIPY derivative designed for use as a fluorescent probe targeting GFP-labeled muscarinic M1 receptors. This compound exhibits strong fluorescence properties, enabling effective visualization and study of receptor interactions and dynamics in biological systems. Its application in research enhances the understanding of muscarinic receptor function and signaling pathways.

Cat. No.

A43767

CAS No.

1236310-96-5

BOCA-1-BG

BOCA-1-BG is a BODIPY-labeled SNAP tag fluorescence probe designed for the detection of intracellular Ca2+ concentration. This compound functions as a highly sensitive fluorescent indicator for Ca2+, enabling real-time monitoring of calcium levels in various biological research applications. It is suitable for use in studies involving calcium signaling pathways and cellular responses to calcium fluctuations.

Cat. No.

A43853

CAS No.

150152-63-9

BODIPY TR methyl ester

BODIPY TR methyl ester is a lipophilic dye that serves as a GFP counterstain, primarily targeting endomembranous organelles. This red fluorescent vital dye exhibits excitation at 568 nm and emission at 625 nm, allowing for effective visualization of cell nuclei and cellular morphology within embryonic tissues. It is particularly useful for delineating the boundaries of organ-forming tissues throughout the embryo, thereby enhancing the study of developmental processes.

Cat. No.

A43859

CAS No.

1181844-41-6

o-Pah

o-Pah is a BODIPY derivative that features -NH2 and -OH substitutions on the meso-phenyl group. This compound is notable for its metal-induced J-aggregation when exposed to Cu2+, as well as a significant fluorescence enhancement in the presence of Hg2+ (Ex/Em = 483/(495-600) nm). o-Pah is useful for applications in metal ion detection and environmental monitoring, enabling researchers to explore metal interactions in biological systems.

Cat. No.

A44308

CAS No.

150173-78-7

BODIPY 576/589

BODIPY 576/589 is a near-infrared (NIR) fluorophore that exhibits strong fluorescence with an emission and excitation maximum at 589 nm and 576 nm, respectively. This compound features a free carboxylic acid (-COOH) group, making it suitable for various bioconjugation applications. BODIPY 576/589 is particularly useful in fluorescence imaging, enabling sensitive detection of biomolecules in live cells and tissues. Its long-wavelength properties allow for reduced background fluorescence, facilitating enhanced signal visibility in biological assays.

Cat. No.

A44645

CAS No.

2068027-79-0

PYBG-BODIPY

PYBG-BODIPY is a fluorochrome that serves as a vital tool for live cell imaging. This dye specifically labels genetically encoded SNAP-tags, enabling precise visualization and tracking of biomolecules within cellular environments. Its high specificity and efficiency make PYBG-BODIPY valuable for applications in cellular biology and molecular imaging studies.

Cat. No.

A44800

CAS No.

287715-95-1

ER-Tracker Blue-White DPX

ER-Tracker Blue-White DPX is a selective probe for the endoplasmic reticulum, designed for live-cell imaging applications. This BODIPY-based dye, featuring a Glibenclamide derivative, exhibits high fluorescence stability and an optimal extinction coefficient while remaining non-toxic at low concentrations. It is particularly useful in studying cellular dynamics and protein localization within the endoplasmic reticulum. Note that while it is not optimal for fixed cells, aldehyde fixation can preserve partial fluorescence, with an excitation/emission range of 374/430-640 nm.

Cat. No.

A44801

CAS No.

571186-05-5

BODIPY TR Ceramide

Synonyms: Golgi-Red Tracke

BODIPY TR Ceramide is a Golgi apparatus probe that targets ceramide transport pathways to facilitate specific labeling of the Golgi apparatus. This BODIPY-labeled ceramide derivative is synthesized in the endoplasmic reticulum and utilizes ceramide transport protein (CERT) or vesicular translocation for localization. BODIPY TR Ceramide enables visualization of individual cells, making it a valuable tool for studying Golgi morphology and function. The excitation and emission wavelengths are 589 nm and 616 nm, respectively.

Cat. No.

A44813

CAS No.

1031443-55-6

2,6-Diiodo-BODIPY 493/503

Synonyms: 2,6-Diiodo-Pyrromethene 546

2,6-Diiodo-BODIPY 493/503 is a fluorescent dye characterized by diiodo substitution at the 2,6 positions of the pyrrole ring. This modification imparts red fluorescence, making it suitable for various applications in bioimaging and cellular studies. Its distinct optical properties enable researchers to utilize this compound in tracking cellular processes and visualizing biomolecules in live-cell assays.