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Erastin

Catalog No.: A13822

VDAC inhibitor

Erastin

Erastin Chemical Structure

CAS NO. 571203-78-6

Erastin is a cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality in cells with H-Ras mutations.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
25 mg
$250.00
50 mg
$350.00
10mM * 1mL in DMSO
$135.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yuki Shibata, .et al. Transferrin-based radiolabeled probe predicts the sensitivity of human renal cancer cell lines to ferroptosis inducer erastin, Biochem Biophys Rep, 2021, Feb 24;26 PMID: 33681481
  • Shibata Y, .et al. Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo, PLoS One, 2019, Dec 4;14(12):e0225931 PMID: 31800616

Biological Activity

Erastin is a cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality in cells with H-Ras mutations.
Targets
Ferroptosis
In vitro (25°C) DMSO 17 mg/mL (31.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5%DMSO+40%PEG 300+5%Tween80+ddH2O 1.66 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.28 mL 91.4 mL 182.8 mL
0.5 mM 3.66 mL 18.28 mL 36.56 mL
1 mM 1.83 mL 9.14 mL 18.28 mL
5 mM 0.37 mL 1.83 mL 3.66 mL

*The above data is based on the productmolecular weight 547.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13822
Actions Inhibitor
CAS No. 571203-78-6
Formula C30H31ClN4O4
M. Wt 547.04
Purity >98%
SMILES CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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