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- Yuki Shibata, .et al. Transferrin-based radiolabeled probe predicts the sensitivity of human renal cancer cell lines to ferroptosis inducer erastin, Biochem Biophys Rep, 2021, Feb 24;26 PMID: 33681481
- Shibata Y, .et al. Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo, PLoS One, 2019, Dec 4;14(12):e0225931 PMID: 31800616
Biological Activity
Erastin is a cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality in cells with H-Ras mutations.
Targets
| Ferroptosis | ||||
| In vitro (25°C) | DMSO | 17 mg/mL (31.07 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5%DMSO+40%PEG 300+5%Tween80+ddH2O | 1.66 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.28 mL | 91.4 mL | 182.8 mL |
| 0.5 mM | 3.66 mL | 18.28 mL | 36.56 mL |
| 1 mM | 1.83 mL | 9.14 mL | 18.28 mL |
| 5 mM | 0.37 mL | 1.83 mL | 3.66 mL |
*The above data is based on the productmolecular weight 547.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13822 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 571203-78-6 |
| Formula | C30H31ClN4O4 |
| M. Wt | 547.04 |
| Purity | >98% |
| SMILES | CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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