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Esculeoside A

Catalog No.: A35469
Steroidal Alkaloid Glycoside
Esculeoside A is a spirosolane-type steroidal alkaloid glycoside that primarily targets NF-κB and Nrf2/Keap1 signaling pathways. This compound exhibits significant cardioprotective and hypoglycemic properties, regulating glucose metabolism and modulating lipid profiles. Research applications include the study of diabetic cardiomyopathy, type 2 diabetes, atopic dermatitis, tumors, and atherosclerotic diseases. Additionally, Esculeoside A inhibits dendritic cell maturation and T-cell proliferation, and exhibits anti-tumor activity against breast cancer and melanoma cells.
Esculeoside A 532387-86-3 Steroidal Alkaloid Glycoside
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionEsculeoside A is a spirosolane-type steroidal alkaloid glycoside that primarily targets NF-κB and Nrf2/Keap1 signaling pathways. This compound exhibits significant cardioprotective and hypoglycemic properties, regulating glucose metabolism and modulating lipid profiles. Research applications include the study of diabetic cardiomyopathy, type 2 diabetes, atopic dermatitis, tumors, and atherosclerotic diseases. Additionally, Esculeoside A inhibits dendritic cell maturation and T-cell proliferation, and exhibits anti-tumor activity against breast cancer and melanoma cells.
Product Information
Catalog NumA35469
FormulaC58H95NO29
Molecular Weight1270.36
CAS Number532387-86-3
SMILESC[C@@H]1[C@@]2([C@H](C[C@@H](CN2)CO[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)OC(C)=O)O[C@]4([H])[C@@]1([H])[C@@]5([C@@]([C@@]6([H])[C@]([C@@]7([C@@](C[C@H](CC7)O[C@@H]8O[C@@H]([C@@H]([C@@H]([C@H]8O)O)O[C@H]9[C@@H]([C@H]([C@@H]([C@H](O9)CO)O)O[C@H]%10[C@@H]([C@H]([C@@H](CO%10)O)O)O)O[C@@H]%11O[C@@H]([C@H]([C@@H]([C@H]%11O)O)O)CO)CO)([H])CC6)C)([H])CC5)([H])C4)C
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Natural Products
NF-κB/IκB > NF-κB