Fig. 1 · Structure
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Estradiol 3-glucuronide sodium
Estrogen Metabolite
Estradiol 3-glucuronide sodium is an estrogen metabolite that serves as a glucuronide conjugate, formed in tissues like the liver through the action of uridine diphosphate glucuronosyltransferase. It acts as a potent substrate for the multidrug resistance protein 2 (Mrp2), with an S50 value of 55.7 μM. This compound plays a critical role in hepatobiliary transport, utilizing basolateral uptake via organic anion-transporting polypeptides OATP1B1, OATP1B3, and OATP2B1, as well as apical efflux through MRP2 and breast cancer resistance protein (BCRP). Its applications extend to studies on estrogen metabolism and transport mechanisms in liver physiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 14982-12-8 |
| Applications | Estrogen Metabolite |
| Formula | C24H31NaO8 |
| Molecular Weight | 470.49 |
| SMILES | C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)C(O[Na])=O)C=C4CC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.