Fig. 1 · Structure
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Estradiol 3-glucuronide
Estrogen Metabolite
Estradiol 3-glucuronide is a glucuronide conjugate and an important metabolite of estradiol, synthesized through the action of uridine diphosphate glucuronosyltransferases primarily in the liver. This compound serves as a potent substrate for MRP2, exhibiting an S50 value of 55.7 μM. Estradiol 3-glucuronide plays a crucial role in hepatobiliary transport mechanisms, involving basolateral uptake via OATP1B1, OATP1B3, and OATP2B1, along with apical efflux through MRP2 and BCRP. Its study is significant in understanding estrogen metabolism and transport in hepatic tissues.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 15270-30-1 |
| Applications | Estrogen Metabolite |
| Formula | C24H32O8 |
| Molecular Weight | 448.51 |
| SMILES | C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)C(O)=O)C=C4CC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.