Fenbufen-d9 is a deuterium-labeled derivative of Fenbufen, a non-steroidal anti-inflammatory drug (NSAID) exhibiting potent antipyretic effects. It targets cyclooxygenase enzymes COX-1 and COX-2, demonstrating inhibitory activities with IC50 values of 3.9 μM and 8.1 μM, respectively. Fenbufen has shown significant efficacy in various preclinical animal models, including carrageenan-induced edema, UV erythema, and adjuvant arthritis. Additionally, it inhibits multiple caspases (caspase-1, 3, 4, 5, 9), making it a valuable tool for research in inflammation and apoptosis.
Fenbufen-d9 is a deuterium-labeled derivative of Fenbufen, a non-steroidal anti-inflammatory drug (NSAID) exhibiting potent antipyretic effects. It targets cyclooxygenase enzymes COX-1 and COX-2, demonstrating inhibitory activities with IC50 values of 3.9 μM and 8.1 μM, respectively. Fenbufen has shown significant efficacy in various preclinical animal models, including carrageenan-induced edema, UV erythema, and adjuvant arthritis. Additionally, it inhibits multiple caspases (caspase-1, 3, 4, 5, 9), making it a valuable tool for research in inflammation and apoptosis.
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