Ferfluor-1 is a potent ferroptosis inhibitor, demonstrating EC50 values of 57 nM in HT108 cells, 75 nM in OS-RC-2 cells, and 2.3 nM in SH-SY5Y neuroblastoma cells. This ratiometric photoluminescent probe is capable of crossing the blood-brain barrier, making it an effective tool for monitoring ferroptotic changes in cellular environments. Ferfluor-1 shows promise in research applications related to neurodegenerative diseases, such as stroke and Parkinson's disease, by mitigating the effects of ferroptosis in in vivo models.
Ferfluor-1 is a potent ferroptosis inhibitor, demonstrating EC50 values of 57 nM in HT108 cells, 75 nM in OS-RC-2 cells, and 2.3 nM in SH-SY5Y neuroblastoma cells. This ratiometric photoluminescent probe is capable of crossing the blood-brain barrier, making it an effective tool for monitoring ferroptotic changes in cellular environments. Ferfluor-1 shows promise in research applications related to neurodegenerative diseases, such as stroke and Parkinson's disease, by mitigating the effects of ferroptosis in in vivo models.
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