Ferroptosis-IN-21 is a selective ferroptosis inhibitor that mitigates renal ischemia/reperfusion (I/R) injury by suppressing ferroptosis and effectively scavenging peroxyl radicals. Demonstrating nanomolar potency, it exhibits significant anti-ferroptotic activity in renal tubular epithelial cells, leading to a marked reduction in lipid reactive oxygen species (ROS) and lipid peroxidation biomarkers such as 4-hydroxynonenal. In preclinical studies, Ferroptosis-IN-21 has shown to alleviate histological damage and functional impairment in mice models of renal I/R injury, making it a valuable reagent for research in ferroptosis-targeted therapeutic development.
Ferroptosis-IN-21 is a selective ferroptosis inhibitor that mitigates renal ischemia/reperfusion (I/R) injury by suppressing ferroptosis and effectively scavenging peroxyl radicals. Demonstrating nanomolar potency, it exhibits significant anti-ferroptotic activity in renal tubular epithelial cells, leading to a marked reduction in lipid reactive oxygen species (ROS) and lipid peroxidation biomarkers such as 4-hydroxynonenal. In preclinical studies, Ferroptosis-IN-21 has shown to alleviate histological damage and functional impairment in mice models of renal I/R injury, making it a valuable reagent for research in ferroptosis-targeted therapeutic development.
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