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Fig. 1 · Structure
Cat. No.
A22459
CAS No.
525-82-6
Formula
C15H10O2
Mol. Weight
222.24

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Flavone

antioxidant agent

Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
BALB/3T3 IC50 287.1 μM Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay [PMID: 10096863]
Caco-2 IC50 21.01 μM Cytotoxicity in human Caco2 cells after 72 hrs by MTT assay [PMID: 28793973]
H9 EC50 50 μM Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay [PMID: 8158164]
H9 IC50 68 μM Cytotoxicity against human H9 cells after 3 days [PMID: 8158164]
HepG2 GI50 50.6 μM Cytotoxicity against Homo sapiens (human) HepG2 cells after 48 hr by SRB assay 10.1007/s00044-012-0423-1
MCF7 IC50 0.3 μM Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 6 days by SRB assay [PMID: 33257172]
MCF7 IC50 26 μM Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining [PMID: 21354800]
MCF7 GI50 69.3 μM Cytotoxicity against Homo sapiens (human) MCF7 cells after 48 hr by SRB assay 10.1007/s00044-012-0423-1
MDCK IC50 17 μM Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining [PMID: 21354800]
Monocyte IC50 166 μM Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA [PMID: 10096854]
Neutrophil IC50 57 μM Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of superoxide anion radical-induced lucigenin oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay [PMID: 23871908]
Neutrophil IC50 64.9 μM Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of HOCl-induced oxidation of APF after 6 mins by fluorescence assay [PMID: 23871908]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 525-82-6
Applications antioxidant agent
Formula C15H10O2
Molecular Weight 222.24
Synonyms 2-Phenyl-4-chromone
SMILES
O=C1C=C(C2=CC=CC=C2)OC3=CC=CC=C13

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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