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Fmoc-MMAE

Catalog No.: A41010
ADC Cytotoxin
Fmoc-MMAE is a protective group-conjugated derivative of monomethyl auristatin E (MMAE), functioning primarily as a tubulin inhibitor. This compound exhibits potent cytotoxicity, making it valuable in the design and development of antibody-drug conjugates (ADCs). Its application in ADC synthesis allows for targeted delivery of cytotoxic agents to cancer cells, enhancing therapeutic efficacy while minimizing off-target effects.
Fmoc-MMAE 474645-26-6 ADC Cytotoxin
Grouped product items
Size Price Stock Qty
50mg
$70.00
In stock
100mg
$110.00
In stock
500mg
$240.00
In stock
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Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionFmoc-MMAE is a protective group-conjugated derivative of monomethyl auristatin E (MMAE), functioning primarily as a tubulin inhibitor. This compound exhibits potent cytotoxicity, making it valuable in the design and development of antibody-drug conjugates (ADCs). Its application in ADC synthesis allows for targeted delivery of cytotoxic agents to cancer cells, enhancing therapeutic efficacy while minimizing off-target effects.
Product Information
Catalog NumA41010
FormulaC54H77N5O9
Molecular Weight940.22
CAS Number474645-26-6
SMILESCC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3C4=C(C=CC=C4)C5=C3C=CC=C5)=O)C)=O)=O)C
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Antibody-drug Conjugates (ADC) > ADC Payload (ADC Cytotoxin)