Signaling Pathway
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| Discription | Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity. | ||
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| Targets |
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| Catalog Num | A12954 |
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| Formula | C39H67N5O7 |
| Molecular Weight | 717.98 |
| CAS Number | 474645-27-7 |
| SMILES | CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC |
| Synonyms | Monomethylauristatin E, MMAE |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | 93 mg/mL (129.52 mM) | |
| Water | Insoluble | ||
| Ethanol | 93 mg/mL (129.52 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.93 mL | 69.64 mL | 139.28 mL |
| 0.5 mM | 2.79 mL | 13.93 mL | 27.86 mL |
| 1 mM | 1.39 mL | 6.96 mL | 13.93 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.79 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
