Fig. 1 · Structure
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Fudapirine
Anti-tuberculosis Agent
Fudapirine is an anti-tuberculosis agent that demonstrates significant anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv while exhibiting low cytotoxicity. It shows potent efficacy with MIC50 values of 0.083 μg/mL for drug-susceptible tuberculosis (DS-TB) and 0.11 μg/mL for multidrug-resistant tuberculosis (MDR-TB) strains. Additionally, Fudapirine inhibits the hERG channel with an IC50 of 1.89 μM, highlighting its potential utility in pharmacological studies related to cardiac safety.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1859978-72-5 |
| Applications | Anti-tuberculosis Agent |
| Formula | C34H33ClN2O2 |
| Molecular Weight | 537.09 |
| Synonyms | WX-081 |
| SMILES | CN(C)CC[C@@](O)(C1=CC=CC2=C1C=CC=C2)[C@H](C3=CC=CC=C3)C4=C(N=CC(C5=CC=C(C=C5)Cl)=C4)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.