Fig. 1 · Structure
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Ganaplacide hydrochloride
Antimalarial Agent
Ganaplacide hydrochloride is a first-in-class, orally active imidazolopiperazine antimalarial agent designed to target Plasmodium species. It exhibits potent activity against a wide range of malaria-causing parasites, including those that exhibit drug resistance. This compound demonstrates parasiticidal effects against both the asexual and sexual blood stages, as well as the liver stages of the parasite, making it valuable for research applications in malaria therapeutics and resistance studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2751586-94-2 |
| Applications | Antimalarial Agent |
| Formula | C22H24ClF2N5O |
| Molecular Weight | 447.91 |
| Synonyms | KAF156 hydrochloride; GNF156 hydrochloride |
| SMILES | FC(C=C1)=CC=C1C2=C(N3C(C(C)(N(C(CN)=O)CC3)C)=N2)NC4=CC=C(F)C=C4.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.