Fig. 1 · Structure
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Ganaplacide
Antimalarial Agent
Ganaplacide is a first-in-class, orally active imidazolopiperazine antimalarial agent targeting various stages of the Plasmodium life cycle. Demonstrating activity against a wide range of Plasmodium species, including drug-resistant strains, Ganaplacide exhibits parasiticidal effects on both asexual and sexual blood stages, as well as liver stages of the parasite. This compound is valuable for research into novel antimalarial therapies and for understanding mechanisms of drug resistance in malaria.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1261113-96-5 |
| Applications | Antimalarial Agent |
| Formula | C22H23F2N5O |
| Molecular Weight | 411.45 |
| Synonyms | KAF156; GNF156 |
| SMILES | FC(C=C1)=CC=C1C2=C(N3C(C(C)(N(C(CN)=O)CC3)C)=N2)NC4=CC=C(F)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.