GSK1034702 hydrochloride is a potent allosteric agonist of the M1 muscarinic acetylcholine receptor (mAChR), with a pEC50 value of 8.1, capable of crossing the blood-brain barrier. This compound activates the Gq/11 protein-mediated signaling pathway, leading to enhanced neuronal firing and long-term potentiation (LTP) in the hippocampal CA1 region. GSK1034702 hydrochloride is valuable for investigating cognitive impairments associated with neurological conditions, such as Alzheimer's disease, and demonstrates pro-cognitive effects in animal models, especially relevant in studies of nicotine withdrawal-induced cognitive dysfunction. Potential side effects related to peripheral M receptor activation, such as gastrointestinal reactions, should be considered in research applications.
GSK1034702 hydrochloride is a potent allosteric agonist of the M1 muscarinic acetylcholine receptor (mAChR), with a pEC50 value of 8.1, capable of crossing the blood-brain barrier. This compound activates the Gq/11 protein-mediated signaling pathway, leading to enhanced neuronal firing and long-term potentiation (LTP) in the hippocampal CA1 region. GSK1034702 hydrochloride is valuable for investigating cognitive impairments associated with neurological conditions, such as Alzheimer's disease, and demonstrates pro-cognitive effects in animal models, especially relevant in studies of nicotine withdrawal-induced cognitive dysfunction. Potential side effects related to peripheral M receptor activation, such as gastrointestinal reactions, should be considered in research applications.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
