Fig. 1 · Structure
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GWP-042
Antimicrobial Agent
GWP-042 is a potent inhibitor of mycobacterial alanine dehydrogenase (Ald, Rv2780), exhibiting an IC50 of 0.21 μM. This compound demonstrates significant antimicrobial activity against Mycobacterium tuberculosis in vivo, making it a valuable tool for research focused on tuberculosis and related mycobacterial infections. Its specific targeting of Ald highlights its potential application in antibiotic development and mycobacterial metabolic studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1645486-93-6 |
| Applications | Antimicrobial Agent |
| Formula | C14H15FN4O2 |
| Molecular Weight | 290.29 |
| SMILES | O=C([C@@H]1CCCO1)NC2=NN=C(N2)CC3=CC(F)=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.