Fig. 1 · Structure
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HC-067047 hydrochloride
Cat. No.
A68866
CAS
1481646-76-7
TRPV4 Antagonist
HC-067047 hydrochloride is a potent and selective antagonist of the Transient Receptor Potential Vanilloid 4 (TRPV4). It effectively inhibits TRPV4 currents in human, rat, and mouse orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively. This compound is valuable for research into TRPV4-related physiological processes and the development of therapeutic strategies targeting this ion channel.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1481646-76-7 |
| Applications | TRPV4 Antagonist |
| Formula | C26H29ClF3N3O2 |
| Molecular Weight | 507.98 |
| SMILES | CC1=C(C(NC2=CC(C(F)(F)F)=CC=C2)=O)C=C(C3=CC=CC=C3)N1CCCN4CCOCC4.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.