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TRPV4 antagonist
In Stock
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| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| CHO-K1 | IC50 | 57 nM | Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FLIPR assay | [PMID: 27637151] |
| HEK293 | IC50 | 48 nM | Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by Whole cell patch-clamp method | [PMID: 28523109] |
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 883031-03-6 |
| Applications | TRPV4 antagonist |
| Formula | C26H28F3N3O2 |
| Molecular Weight | 471.51 |
| SMILES | O=C(C1=C(C)N(CCCN2CCOCC2)C(C3=CC=CC=C3)=C1)NC4=CC=CC(C(F)(F)F)=C4 |
| Solvent | Reported Solubility |
|---|---|
| DMSO | 87 mg/mL (184.5 mM) |
| Water | Insoluble |
| Ethanol | 5 mg/mL (10.6 mM) |
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
