HIV-1 inhibitor-22 is a potent non-nucleoside reverse transcriptase (RT) inhibitor targeting HIV-1. It demonstrates significant antiretroviral activity, exhibiting IC50 values of 3.63 μM against HIV-1 RT and EC50 values of 0.304 μM and 0.201 μM against HIV-1 wild-type and K103N strains, respectively. Additionally, HIV-1 inhibitor-22 shows low cytotoxicity, with a CC50 greater than 227 μM, making it a valuable tool for investigating HIV-1 replication and resistance mechanisms in research applications.
HIV-1 inhibitor-22 is a potent non-nucleoside reverse transcriptase (RT) inhibitor targeting HIV-1. It demonstrates significant antiretroviral activity, exhibiting IC50 values of 3.63 μM against HIV-1 RT and EC50 values of 0.304 μM and 0.201 μM against HIV-1 wild-type and K103N strains, respectively. Additionally, HIV-1 inhibitor-22 shows low cytotoxicity, with a CC50 greater than 227 μM, making it a valuable tool for investigating HIV-1 replication and resistance mechanisms in research applications.
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