HIV-1 Inhibitor-23 is a potent non-nucleoside reverse transcriptase inhibitor targeting HIV-1. It exhibits effective inhibition with EC50 values of 24.9 nM for wild-type HIV-1 and 10.4 nM for the HIV-1 K103N mutant. Additionally, HIV-1 Inhibitor-23 demonstrates low cytotoxicity with a CC50 exceeding 221 μM and displays favorable stability in vitro under microsomal conditions, making it a valuable tool for HIV research and drug development.
HIV-1 Inhibitor-23 is a potent non-nucleoside reverse transcriptase inhibitor targeting HIV-1. It exhibits effective inhibition with EC50 values of 24.9 nM for wild-type HIV-1 and 10.4 nM for the HIV-1 K103N mutant. Additionally, HIV-1 Inhibitor-23 demonstrates low cytotoxicity with a CC50 exceeding 221 μM and displays favorable stability in vitro under microsomal conditions, making it a valuable tool for HIV research and drug development.
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