HKSOX-1 is a fluorescent dye specifically designed for the sensitive and selective detection of superoxide anion radicals (O2•−) within cellular environments. Utilizing an aryl trifluoromethanesulfonate moiety, this probe undergoes O2•−-mediated cleavage, resulting in the release of a free phenol and subsequent fluorescence emission. HKSOX-1 exhibits high specificity and sensitivity across various pH levels and is resistant to interference from common oxidants and reductants in biological systems. Its derivative, HKSOX-1r, is optimized for cellular retention and has been effectively utilized in assays such as confocal microscopy, flow cytometry, and zebrafish embryo research, making it valuable for studies related to O2•− in inflammation and mitochondrial stress.
HKSOX-1 is a fluorescent dye specifically designed for the sensitive and selective detection of superoxide anion radicals (O2•−) within cellular environments. Utilizing an aryl trifluoromethanesulfonate moiety, this probe undergoes O2•−-mediated cleavage, resulting in the release of a free phenol and subsequent fluorescence emission. HKSOX-1 exhibits high specificity and sensitivity across various pH levels and is resistant to interference from common oxidants and reductants in biological systems. Its derivative, HKSOX-1r, is optimized for cellular retention and has been effectively utilized in assays such as confocal microscopy, flow cytometry, and zebrafish embryo research, making it valuable for studies related to O2•− in inflammation and mitochondrial stress.
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