We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

cGAS

cGAS inhibitors act on the cyclic dinucleotide synthase that senses double-stranded DNA in the cytosol. Bound to DNA, the enzyme makes the second messenger 2'3'-cyclic guanosine monophosphate-adenosine monophosphate (2'3'-cGAMP) from ATP and GTP. In 2013 this pathway was shown to activate stimulator of interferon genes (STING) and type I interferon production. RU.521 and XQ2B inhibit cGAS directly, and RU.521 lowered interferon expression in macrophages from autoimmune mice. Many other products are ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitors, such as Enpp-1-IN-2. ENPP1 hydrolyzes extracellular 2'3'-cGAMP, so these compounds protect the messenger rather than block its synthesis. The downstream receptor of 2'3'-cGAMP has its own category, STING.

2 Items

  • QKY-613
    Cat. No.
    A64590
    CAS No.
    2646682-38-2

    QKY-613

    QKY-613 is a cGAS activator designed to enhance immune surveillance through nucleic acid modification pathways. As a prodrug, QKY-613 promotes the incorporation of 6mdA (N6-methyldeoxyadenosine) into viral DNA, which increases the phase separation potential and activates cGAS. In studies using virus-infected mouse models, QKY-613 demonstrated a significant reduction in mortality among aged mice. This compound is valuable for research investigating nucleic acid modification mechanisms and their role in immune response enhancement.

    In stock View Details
    5 mg
    $200.00
    10 mg
    $330.00
    All 5 sizes
  • MS7829
    Cat. No.
    A64593
    CAS No.
    3060519-67-4

    MS7829

    MS7829 is a deubiquitinase-targeting chimera (DUBTAC) designed to activate cyclic GMP-AMP synthase (cGAS). By recruiting OTUB1 and covalently binding to it, MS7829 enhances cGAS protein stability and promotes activation of the cGAS-STING-IRF3 innate immune signaling pathway in an OTUB1-dependent manner. This reagent is valuable for cancer-related research, particularly in studies focusing on innate immunity and tumor microenvironment interactions.

    View Details

    Out of stock

    All 3 sizes

2 Items

Added to your cart

View Cart Checkout

    Loading...