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FLAP

FLAP inhibitors act on 5-lipoxygenase-activating protein (FLAP), which is needed for leukotriene synthesis. FLAP is a nuclear membrane protein that presents arachidonic acid to 5-lipoxygenase, and it was identified as the membrane target of the leukotriene inhibitor MK-886. The crystal structure of human FLAP bound to inhibitors shows a binding pocket within the membrane. FLAP inhibitors are used to study leukotriene-driven inflammation in airway, vascular and immune cell models. Listed compounds include MK-886 sodium salt, quiflapon, fiboflapon, AZD6642 and AM679.

2 Items

  • ALR-6
    Cat. No.
    A64668
    CAS No.
    6621-92-7

    ALR-6

    ALR-6 is a selective antagonist of the 5-lipoxygenase-activating protein (FLAP), known for its anti-inflammatory properties. This compound effectively inhibits the formation of 5-LOX products by more than 80% in pro-inflammatory M1 monocyte-derived macrophages (MDM), while demonstrating minimal direct inhibition of 5-LOX activity. ALR-6 is valuable for research applications aimed at exploring inflammatory pathways and potential therapeutic interventions in inflammatory diseases.

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  • ALR-27
    Cat. No.
    A64671
    CAS No.
    903639-13-4

    ALR-27

    ALR-27 is a selective antagonist of the 5-lipoxygenase activating protein (FLAP), exhibiting significant anti-inflammatory properties. This compound effectively inhibits the formation of 5-LOX products by more than 80% in pro-inflammatory M1 macrophage-derived macrophages (M1-MDM), without directly inhibiting 5-LOX activity. Additionally, ALR-27 reduces the production of prostaglandins and leukotrienes in neutrophils while promoting the synthesis of specialized pro-resolving mediators in distinct human macrophage phenotypes. These characteristics make ALR-27 valuable for research in inflammation and immune response modulation.

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