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gp120/CD4

gp120/CD4 inhibitors block binding between the HIV envelope glycoprotein gp120 and the CD4 receptor on host cells. Human immunodeficiency virus (HIV) enters T cells when gp120 binds CD4 and then a co-receptor, which triggers membrane fusion. Attachment inhibitors bind gp120 and hold it in a shape that cannot engage CD4, while other compounds target CD4 or mimic its binding site. Compounds in this category are used in laboratory studies of viral entry and envelope protein structure.

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  • Forigerimod
    Cat. No.
    A39531
    CAS No.
    497156-60-2

    Forigerimod

    Synonyms: IPP-201101

    Forigerimod is a CD4 T-cell modulator that functions by inhibiting autophagy through its active peptide fragment derived from U1 small nuclear ribonucleoprotein 70 kDa, which is phosphorylated at Ser140. This compound is particularly valuable in the investigation of autoimmune disorders, including systemic lupus erythematosus (SLE), due to its ability to modulate T-cell responses. Researchers may utilize Forigerimod to explore therapeutic strategies targeting dysregulated immune responses in various autoimmune conditions.

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