IFNAR

Cat. No.

A33230

CAS No.

691868-88-9

RO8191

Synonyms: CDM-3008; RO4948191

RO8191 is an imidazonaphthyridine compound that functions as a potent agonist of the interferon (IFN) receptor, specifically targeting the IFNα/β receptor 2 (IFNAR2). This compound stimulates the expression of interferon-stimulated genes (ISGs) and promotes JAK/STAT phosphorylation, demonstrating significant antiviral activity against hepatitis C virus (HCV) and encephalomyocarditis virus (EMCV), with an IC50 of 200 nM for HCV replicon. Additionally, RO8191 acts as a cccDNA modulator, exhibiting interferon-like activity and providing anti-hepatitis B virus (HBV) effects, making it a valuable tool for research in virology and immune modulation.

Cat. No.

A64859

CAS No.

1465774-27-9

2'2'-cGAMP

2'2'-cGAMP is a synthetic cyclic dinucleotide (CDN) that targets the STING (Stimulator of Interferon Genes) pathway, playing a crucial role in the immune response. It effectively induces the production of interferon-beta (IFN-β), a key cytokine involved in antiviral defense. While 2'2'-cGAMP exhibits a weaker affinity for STING compared to 2'3'-cGAMP, it demonstrates a stronger interaction than other CDNs, making it valuable for research in immunology and therapeutic applications related to immune modulation.

Cat. No.

A64872

CAS No.

2978670-53-8

Antitumor agent-210

Antitumor agent-210 is an NK cell activator known for enhancing the activation and degranulation of natural killer (NK) cells. It exerts a modest proliferative effect on NK92 cells, significantly increasing their cytotoxicity against tumor cells. This compound promotes the release of key cytokines, including granzyme B, perforin, and IFN-γ, and has demonstrated efficacy in reducing lung metastatic lesions in murine models. Antitumor agent-210 is a valuable reagent for researching melanoma lung metastasis and other cancer-related immunological studies.