We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

IFNAR

IFNAR modulators act on the type I interferon receptor (IFNAR), which binds interferon alpha and beta. The receptor has two chains: IFNAR1 was cloned as a functional human interferon alpha receptor, and IFNAR2 was later characterized as the ligand-binding chain. Mice lacking type I interferon signaling are highly susceptible to viral infection. Products here include RO8191, a small-molecule IFNAR agonist, and IFN alpha-IFNAR-IN-1 hydrochloride, which blocks the ligand-receptor interaction. The section also lists 2',3'-cGAMP, an upstream inducer of type I interferon, and IRF5-IN-1, which targets the interferon regulatory factor 5 (IRF5) transcription factor.

2 Items

  • RO8191
    Cat. No.
    A33230
    CAS No.
    691868-88-9

    RO8191

    Synonyms: CDM-3008; RO4948191

    RO8191 is an imidazonaphthyridine compound that functions as a potent agonist of the interferon (IFN) receptor, specifically targeting the IFNα/β receptor 2 (IFNAR2). This compound stimulates the expression of interferon-stimulated genes (ISGs) and promotes JAK/STAT phosphorylation, demonstrating significant antiviral activity against hepatitis C virus (HCV) and encephalomyocarditis virus (EMCV), with an IC50 of 200 nM for HCV replicon. Additionally, RO8191 acts as a cccDNA modulator, exhibiting interferon-like activity and providing anti-hepatitis B virus (HBV) effects, making it a valuable tool for research in virology and immune modulation.

    In stock View Details
    1 mg
    $30.00
    2 mg
    $45.00
    All 8 sizes
  • CP-28888
    Cat. No.
    A64873
    CAS No.
    69938-75-6

    CP-28888

    Synonyms: CP 28888-27

    CP-28888 is an interferon alpha/beta receptor (IFNAR) inducer that enhances the immune response by promoting the production of type I interferons. It exhibits greater potency in murine models, making it a valuable tool for studying immune modulation and antiviral responses in preclinical research. Despite its limited efficacy in human trials and lack of antirhinovirus activity, CP-28888 remains a relevant compound in the investigation of therapeutic approaches targeting interferon pathways.

    In stock View Details
    1 mg
    $235.00
    5 mg
    $590.00
    All 5 sizes

2 Items

Added to your cart

View Cart Checkout

    Loading...