STING

Cat. No.

A65601

CAS No.

1307526-16-4

STING ligand-2

STING ligand-2 is a selective ligand for the stimulator of interferon genes (STING) pathway. This compound is integral in the development of PROTAC degraders, specifically STING-IN-10, enabling targeted protein degradation. Its key biological activity is the enhancement of immune responses, making it valuable for research in immunotherapy and cancer treatment applications.

Cat. No.

A65605

CAS No.

79940-41-3

C-di-IMP

Synonyms: Cyclic-di-IMP

C-di-IMP (Cyclic-di-IMP) is a small molecule that acts as a stimulator of the STING (Stimulator of Interferon Genes) pathway. It promotes immune activation and has significant implications in the study of cancer immunotherapy. This compound is valuable for research aimed at enhancing anti-tumor immunity and understanding the role of STING in modulating immune responses.

Cat. No.

A65607

CAS No.

2259308-68-2

STING agonist-11

STING agonist-11 (Compound 92) is a potent small molecule cyclic urea that selectively activates the stimulator of interferon genes (STING) pathway. With an EC50 of 18 nM, it enhances the immune response, making it a valuable tool in immunotherapy research. Its ability to modulate STING activity positions it for potential applications in cancer treatment and infectious disease models.

Cat. No.

A65608

CAS No.

2719001-44-0

STING agonist-31

STING agonist-31 is a potent stimulator of the STING pathway, exhibiting EC50 values of 0.24 μM for human STING (h-STING) and 39.51 μM for mouse STING (m-STING). This compound demonstrates significant antitumor activity, making it an important tool for cancer research. It is suitable for studying the mechanisms of innate immunity and potential therapeutic applications in oncology.

Cat. No.

A65609

CAS No.

2868261-45-2

STING agonist-27

STING Agonist-27 is a non-nucleotide small-molecule compound designed to activate the STING (Stimulator of Interferon Genes) pathway. This agonist showcases significant biological activity against various strains of SARS-CoV, making it valuable for research in antiviral mechanisms and immune modulation. Its application in studies targeting STING activation provides insights into therapeutic strategies for combating viral infections and enhancing innate immunity.

Cat. No.

A65610

CAS No.

2757762-91-5

Antitumor agent-114

Antitumor agent-114 is a potent stimulator of interferon genes (STING) agonist. It effectively activates immune responses, leading to reduced tumor volume in preclinical mouse models of breast cancer. This compound is valuable for research in immunology and cancer therapy, contributing insights into immune modulation and tumor microenvironment interactions.

Cat. No.

A65620

CAS No.

2228893-48-7

Parent CDN

Parent CDN is a cyclic dinucleotide that acts as a Stimulator of Interferon Genes (STING) agonist. It has demonstrated significant anti-tumor activity by enhancing the innate immune response. This compound is utilized in research aimed at understanding immune modulation and cancer immunotherapy.

Cat. No.

A65623

CAS No.

2248444-14-4

(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide

(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide is a potent STING (stimulator of interferon genes) agonist. It exhibits a significant inhibitory effect on 3H-cGAMP binding to STING, with an IC50 value of 14 μM. This compound is valuable for research applications in tumor biology and immune response modulation, particularly in the context of cancer immunotherapy.

Cat. No.

A65625

CAS No.

21829-22-1

Clonixeril

Synonyms: NSC 335504

Clonixeril (NSC 335504) is a non-nucleotide modulator of human STING (hSTING), exhibiting a unique dual mechanism of action. It acts as a weak agonist at micromolar concentrations while demonstrating antagonistic properties of the hSTINGWT pathway at low femtomolar and attomolar levels. Clonixeril effectively reduces hSTING oligomerization, proving useful in elucidating the complexities of STING signaling and its role in immune responses. This compound serves as a valuable tool for research in immunology and drug discovery targeting STING-related pathways.

Cat. No.

A65628

CAS No.

2882097-31-4

STING agonist-43

STING Agonist-43 is a selective STING (Stimulator of Interferon Genes) agonist that activates the cGAMP-dependent STING signaling pathway, with an EC50 of 20.53 μM. This compound enhances STING oligomerization, leading to increased activation and subsequent immune response. In preclinical studies, STING agonist-43 demonstrated antitumor efficacy in a mouse melanoma model, making it a valuable tool for investigating cancer immunity and the potential for immunotherapeutic strategies.

Cat. No.

A65629

CAS No.

2913152-30-2

STING agonist-34

STING agonist-34 is a potent stimulator of the STING pathway, exhibiting an IC50 value of 1.15 μM and an EC50 value of 0.38 μM in THP1 cells. This compound activates the cGAS-STING signaling pathway, promoting type I interferon production and enhancing immune responses. STING agonist-34 is applicable in cancer research and immunotherapy studies, offering potential insights into tumor microenvironments and therapeutic strategies against malignancies.

Cat. No.

A65630

CAS No.

2408723-10-2

STING agonist-25

STING agonist-25 (CF505) is a non-nucleotide small-molecule activator of the Stimulator of Interferon Genes (STING). This compound enhances the phosphorylation of STING, TBK1, and IRF3, leading to elevated levels of pro-inflammatory cytokines such as IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-25 shows potential in antiviral research, particularly against strains of SARS-CoV.

Cat. No.

A65632

CAS No.

2259308-69-3

STING agonist-10

STING agonist-10 is a potent small molecule cyclic urea that activates the Stimulator of Interferon Genes (STING) pathway, with an EC50 of 2600 nM. This compound enhances the immune response by stimulating the production of type I interferons, making it a valuable tool in immunotherapy research. Its ability to modulate STING activity holds potential for applications in the treatment of various cancers and infectious diseases.

Cat. No.

A65636

CAS No.

2082743-99-3

Ulevostinag (isomer 2)

Synonyms: MK-1454 (isomer 2)

Ulevostinag (isomer 2) is a selective STING (Stimulator of Interferon Genes) agonist. It activates the STING pathway, leading to enhanced production of type I interferons and pro-inflammatory cytokines. This compound is primarily utilized in research focused on cancer immunotherapy, infectious diseases, and autoimmune disorders to investigate the therapeutic potential of STING activation in modulating immune responses.

Cat. No.

A65639

CAS No.

702662-64-4

STING modulator-7

STING modulator-7 is a potent modulator of the stimulator of interferon genes (STING), enhancing the signaling pathway associated with innate immune responses. This compound exhibits significant biological activity in activating STING-dependent pathways, promoting type I interferon production and immune cell activation. It is primarily utilized in research applications focused on cancer immunotherapy, infectious disease models, and studies of immune system regulation.

Cat. No.

A65640

CAS No.

2082743-98-2

Ulevostinag (isomer 3)

Synonyms: MK-1454 (isomer 3)

Ulevostinag (isomer 3) is a potent STING (Stimulator of Interferon Genes) agonist that functions through the activation of the STING pathway, leading to the induction of type I interferons and other cytokines. This compound has demonstrated significant biological activity in promoting anti-tumor immune responses, making it an essential tool for cancer immunotherapy research. Its ability to modulate immune signaling pathways positions Ulevostinag (isomer 3) as a valuable reagent in the study of immune activation and anti-cancer strategies.

Cat. No.

A65641

CAS No.

2082743-97-1

Ulevostinag (isomer 4)

Synonyms: MK-1454 (isomer 4)

Ulevostinag (isomer 4) is a potent STING (Stimulator of Interferon Genes) agonist that activates the STING signaling pathway, leading to the production of type I interferons and other pro-inflammatory cytokines. This compound enhances the immune response, making it valuable for research in cancer immunotherapy and infectious disease. Ulevostinag (isomer 4) serves as an important tool for studying STING-mediated pathways and their role in immune modulation.