Fig. 1 · Structure
Documents & Downloads
IPN60090 dihydrochloride
GLS1 Inhibitor
IPN60090 dihydrochloride is a highly selective inhibitor of glutaminase 1 (GLS1) with an IC50 of 31 nM, demonstrating no significant activity against GLS2. This compound exhibits favorable physicochemical and pharmacokinetic properties, making it suitable for in vivo studies. IPN60090 dihydrochloride is primarily utilized in research targeting solid tumors, including lung and ovarian cancers, thereby contributing to the understanding of metabolic pathways in cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2102101-72-2 |
| Applications | GLS1 Inhibitor |
| Formula | C24H29Cl2F3N8O3 |
| Molecular Weight | 605.44 |
| SMILES | O=C(NC)C1=CN(C[C@H](F)CCC2=NN=C(NC(CC3=NC(C)=CC(OC4CC(F)(F)C4)=C3)=O)C=C2)N=N1.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.