Fig. 1 · Structure
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IPN60090
GLS1 Inhibitor
IPN60090 is a potent and selective inhibitor of glutaminase 1 (GLS1), exhibiting an IC50 of 31 nM, with no significant activity against GLS-2. This compound demonstrates favorable physicochemical and pharmacokinetic properties in vivo. IPN60090 is suitable for research into solid tumors, including lung and ovarian cancers, by targeting metabolic pathways critical for tumor progression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1853164-83-6 |
| Applications | GLS1 Inhibitor |
| Formula | C24H27F3N8O3 |
| Molecular Weight | 532.52 |
| SMILES | O=C(NC1=NN=C(CC[C@@H](F)CN2N=NC(C(NC)=O)=C2)C=C1)CC3=NC(C)=CC(OC4CC(F)(F)C4)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.