Fig. 1 · Structure
Documents & Downloads
Iptacopan hydrochloride hydrate
Factor B Inhibitor
Iptacopan hydrochloride hydrate is a selective inhibitor of Factor B, exhibiting an IC50 value of 10 nM and a KD of 7.9 nM. This compound effectively modulates the complement cascade, mitigating hemolysis of red blood cells in paroxysmal nocturnal hemoglobinuria (PNH) and protecting renal cells in immunoglobulin A nephropathy (IgAN) and complement 3 glomerulopathy (C3G). Iptacopan hydrochloride hydrate is a valuable reagent for research into complement-mediated diseases and therapeutic interventions targeting these conditions.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2447007-60-3 |
| Applications | Factor B Inhibitor |
| Formula | C25H33ClN2O5 |
| Molecular Weight | 476.99 |
| Synonyms | LNP023 hydrochloride hydrate |
| SMILES | CC(C=C1OC)=C(NC=C2)C2=C1CN3[C@H](C4=CC=C(C=C4)C(O)=O)C[C@H](CC3)OCC.Cl.O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.