Fig. 1 · Structure
Documents & Downloads
Iptacopan hydrochloride
Factor B Inhibitor
Iptacopan hydrochloride is a highly selective inhibitor of Factor B, exhibiting an IC50 of 10 nM and a KD of 7.9 nM. This compound disrupts the complement cascade, thereby preventing hemolysis in paroxysmal nocturnal hemoglobinuria (PNH) and protecting renal cells in primary immunoglobulin A nephropathy (IgAN) and complement 3 glomerulopathy (C3G). Iptacopan hydrochloride is valuable for research on complement-mediated diseases, facilitating the exploration of therapeutic strategies in these conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1646321-63-2 |
| Applications | Factor B Inhibitor |
| Formula | C25H31ClN2O4 |
| Molecular Weight | 458.98 |
| Synonyms | LNP023 hydrochloride |
| SMILES | O=C(O)C1=CC=C([C@H]2N(CC3=C(OC)C=C(C)C4=C3C=CN4)CC[C@H](OCC)C2)C=C1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.