Fig. 1 · Structure
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Isoleucyl tRNA synthetase-IN-2
IleRS Inhibitor
Isoleucyl tRNA synthetase-IN-2 is a potent and selective inhibitor of isoleucyl-tRNA synthetase (IleRS) with an apparent inhibition constant (Ki,app) of 114 nM. This compound effectively disrupts the function of IleRS, thereby impacting protein synthesis and facilitating research into translational control mechanisms. Its selective inhibition makes it a valuable tool in molecular biology studies focused on aminoacyl-tRNA synthetase pathways and their implications in various diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2494195-61-6 |
| Applications | IleRS Inhibitor |
| Formula | C22H33N5O8S |
| Molecular Weight | 527.59 |
| SMILES | O[C@H]([C@@H]([C@H](OC1)COS(NC([C@@H](N)[C@@H](C)CC)=O)(=O)=O)O)[C@@H]1OCCN2C=C(C3=CC=CC=C3)N=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.