Ivacaftor-d9 is a potent CFTR modulator that enhances CFTR function, demonstrating an EC50 value of 255 nM for potentiation in G551D/F508del human bronchial epithelial cells. As a deuterated analog of Ivacaftor, it exhibits improved stability and pharmacokinetic properties, making it a valuable tool for cystic fibrosis research. Ivacaftor-d9 is suitable for studies aimed at understanding CFTR modulation and its implications in therapeutic development for cystic fibrosis.
Ivacaftor-d9 is a potent CFTR modulator that enhances CFTR function, demonstrating an EC50 value of 255 nM for potentiation in G551D/F508del human bronchial epithelial cells. As a deuterated analog of Ivacaftor, it exhibits improved stability and pharmacokinetic properties, making it a valuable tool for cystic fibrosis research. Ivacaftor-d9 is suitable for studies aimed at understanding CFTR modulation and its implications in therapeutic development for cystic fibrosis.
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