Fig. 1 · Structure
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JAB-3068 hydrochloride
SHP2 Inhibitor
JAB-3068 hydrochloride is a potent inhibitor of SHP2, exhibiting an IC50 value of 25.8 nM. This compound is relevant for research applications investigating the modulation of SHP2 activity, which is implicated in various signaling pathways associated with cancer and immunology. Its inhibition of SHP2 may provide insights into therapeutic strategies targeting related diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2169223-49-6 |
| Applications | SHP2 Inhibitor |
| Formula | C22H27ClF2N6O2S |
| Molecular Weight | 513.00 |
| Synonyms | SHP2-IN-6 hydrochloride |
| SMILES | CC(N1CC(F)(F)C2=C1C=CC=C2SC3=NC=C(N(CC4)CCC54[C@H](N)COC5)N=C3N)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.