Fig. 1 · Structure
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JAB-3068
SHP2 Inhibitor
JAB-3068 is a selective inhibitor of the protein tyrosine phosphatase SHP2, demonstrating an IC50 value of 25.8 nM. This compound has potential applications in cancer research, particularly for targeting SHP2-mediated signaling pathways that influence tumor growth and progression. Its efficacy makes it a valuable tool for investigating the therapeutic potential of SHP2 inhibition in various malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2169223-48-5 |
| Applications | SHP2 Inhibitor |
| Formula | C22H26F2N6O2S |
| Molecular Weight | 476.54 |
| Synonyms | SHP2-IN-6 |
| SMILES | CC(N1CC(F)(F)C2=C1C=CC=C2SC3=NC=C(N(CC4)CCC54[C@H](N)COC5)N=C3N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.