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JNJ-2901

Cytochrome bc1 inhibitor

JNJ-2901 is a selective inhibitor of the cytochrome bc1:aa3 complex in Mycobacterium tuberculosis. It demonstrates significant efficacy in reducing bacterial load in both acute and chronic mouse models of M. tuberculosis H37Rv-ΔcydAB. This compound is valuable for research applications targeting tuberculosis (TB) and can contribute to the development of novel therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2059985-55-4
Applications	Cytochrome bc1 inhibitor
Formula	C₂₄H₂₄ClF₃N₄O₃S
Molecular Weight	540.99
SMILES	CCC1=C(N2C=C(C=CC2=N1)Cl)C(NCC3=CC=C(C=C3)C4CC5(CN(C5)S(=O)(C(F)(F)F)=O)C4)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.