Jun13296 is an orally active quinoline compound that functions as a potent inhibitor of the SARS-CoV-2 papain-like protease, with an IC50 of 0.13 µM and a Ki of 8.8 nM. This reagent demonstrates significant inhibitory activity against various SARS-CoV-2 variants, including those resistant to Nirmatrelvir. In in vivo studies, Jun13296 effectively reduces lung viral titers and mitigates lung tissue damage in models of SARS-CoV-2 infection, making it a valuable tool for COVID-19 research and therapeutic development.
Jun13296 is an orally active quinoline compound that functions as a potent inhibitor of the SARS-CoV-2 papain-like protease, with an IC50 of 0.13 µM and a Ki of 8.8 nM. This reagent demonstrates significant inhibitory activity against various SARS-CoV-2 variants, including those resistant to Nirmatrelvir. In in vivo studies, Jun13296 effectively reduces lung viral titers and mitigates lung tissue damage in models of SARS-CoV-2 infection, making it a valuable tool for COVID-19 research and therapeutic development.
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