KRAS inhibitor-13 is a selective inhibitor targeting the mutant KRAS G12C protein, demonstrating its potency with an IC50 value of 0.883 µM. This compound effectively inhibits phosphorylated ERK (p-ERK) in cell lines, showing IC50s of 5.9 µM in MIA PaCA-2 cells and >100 µM in A549 cells. KRAS inhibitor-13 is poised for research applications focused on pancreatic, colorectal, and lung cancers, providing insights into therapeutic strategies against KRAS-driven malignancies.
KRAS inhibitor-13 is a selective inhibitor targeting the mutant KRAS G12C protein, demonstrating its potency with an IC50 value of 0.883 µM. This compound effectively inhibits phosphorylated ERK (p-ERK) in cell lines, showing IC50s of 5.9 µM in MIA PaCA-2 cells and >100 µM in A549 cells. KRAS inhibitor-13 is poised for research applications focused on pancreatic, colorectal, and lung cancers, providing insights into therapeutic strategies against KRAS-driven malignancies.
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