L-Asparagine-15N2 monohydrate is a stable isotope-labeled analog of the amino acid L-Asparagine. It is critical for leukemic cells and serves as a substrate for the enzyme L-Asparaginase, which facilitates the depletion of asparagine and glutamine, thereby inhibiting protein biosynthesis in lymphoblasts. This process leads to reduced RNA and DNA synthesis and triggers apoptosis, making L-Asparaginase a valuable anti-leukemic agent. L-Asparagine-15N2 monohydrate is applicable in research focused on childhood acute lymphoblastic leukemia, acting as a biomarker and sensor for in-depth studies of cell metabolism in this context.
L-Asparagine-15N2 monohydrate is a stable isotope-labeled analog of the amino acid L-Asparagine. It is critical for leukemic cells and serves as a substrate for the enzyme L-Asparaginase, which facilitates the depletion of asparagine and glutamine, thereby inhibiting protein biosynthesis in lymphoblasts. This process leads to reduced RNA and DNA synthesis and triggers apoptosis, making L-Asparaginase a valuable anti-leukemic agent. L-Asparagine-15N2 monohydrate is applicable in research focused on childhood acute lymphoblastic leukemia, acting as a biomarker and sensor for in-depth studies of cell metabolism in this context.
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