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Biological Activity
Larotaxel is a semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.02 mL | 60.1 mL | 120.21 mL |
| 0.5 mM | 2.4 mL | 12.02 mL | 24.04 mL |
| 1 mM | 1.2 mL | 6.01 mL | 12.02 mL |
| 5 mM | 0.24 mL | 1.2 mL | 2.4 mL |
*The above data is based on the productmolecular weight 831.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18531 |
|---|---|
| CAS No. | 156294-36-9 |
| Formula | C45H53NO14 |
| M. Wt | 831.9 |
| Purity | >98% |
| Synonyms | XRP9881; XRP 9881 XRP-9881; RPR109881; RPR-109881; RPR 109881; RPR109881A; RPR 109881; RPR-109881A; PNU100940; PNU-100940; PNU 100940; Larotaxel. |
| SMILES | CC1=C2[[email protected]](C(=O)[[email protected]]34C[[email protected]]3C[[email protected]@H]5[[email protected]]([[email protected]]4[[email protected]@H]([[email protected]@](C2(C)C)(C[[email protected]@H]1OC(=O)[[email protected]@H]([[email protected]](C6=CC=CC=C6)NC(=O)OC(C)(C)C)O)O)OC(=O)C7=CC=CC=C7)(CO5)OC(=O)C)OC(=O)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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