Fig. 1 · Structure

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LasR antagonist 1

LasR Antagonist

LasR antagonist 1 is a selective antagonist of the LasR receptor, exhibiting an IC50 of 0.4 μM. This compound effectively modulates quorum sensing in the opportunistic pathogen Pseudomonas aeruginosa, making it a valuable tool for studying bacterial communication and biofilm formation. Research applications include investigations into quorum sensing mechanisms and potential therapeutic strategies against P. aeruginosa infections.

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Specifications

Manufacturer Adooq Bioscience
Actions Antagonist
CAS Number 1421464-74-5
Applications LasR Antagonist
Formula C20H15F3N2O3
Molecular Weight 388.34
SMILES
O=C(NCC#CCOC1=CC(C(F)(F)F)=CC=C1)CC2=NOC3=C2C=CC=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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