Leoidin is an inhibitor of the OATP1B1 and OATP1B3 transporters, exhibiting Ki values of 0.08 and 1.84 μM, respectively. This compound effectively blocks sodium fluorescein uptake in CHO cells expressing these transporters. As an antibacterial agent, Leoidin demonstrates activity against both Gram-positive and Gram-negative bacteria by inhibiting phenylalanyl-tRNA synthetase (PheRS) with an IC50 of 42 μM, thereby disrupting bacterial protein synthesis. Leoidin can be isolated from the marine organism L. gangaleoides, making it a valuable tool for microbiological research.
Leoidin is an inhibitor of the OATP1B1 and OATP1B3 transporters, exhibiting Ki values of 0.08 and 1.84 μM, respectively. This compound effectively blocks sodium fluorescein uptake in CHO cells expressing these transporters. As an antibacterial agent, Leoidin demonstrates activity against both Gram-positive and Gram-negative bacteria by inhibiting phenylalanyl-tRNA synthetase (PheRS) with an IC50 of 42 μM, thereby disrupting bacterial protein synthesis. Leoidin can be isolated from the marine organism L. gangaleoides, making it a valuable tool for microbiological research.
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